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Deliverables

Work Package 1

 

Report on data collection on target molecules and on relevant interactions involving antibiotics and anti-cancer drugs (D1.1)

 

Available

 

Report of the intercalibration exercise (D1.6)

 

Available

 

Implementation of GWAVA model to pharmaceuticals (D1.2)

 

Available

 

Corroberation of the GWAVA model by comparison to LF2000-WQX and measured data (D1.3)

 

Available

 

Report of concentrations to which animals and wildlife are exposed (D1.7)

 

Available

 

Revise GWAVA model and provide final predictions for all 27 EU countries (D1.4)

 

Available

 

Prediction of uptake into food crops and accumulation in fish of selected pharmaceuticals, as part of the human exposure assessment (D1.5)

 

Available

 

Work Package 2

 

Report on the different sensitivities of different groups of humans (e.g. healthy adults, infirm adults, foetuses, young children) to low doses of human pharmaceuticals (D2.1)

 

Available

 

Data on the genotoxic effects of selected anticancer drugs on fish, invertebrates, algae and bacteria (D2.2)

 

Available

 

Report on the comparative sensitivities of embryo, juvenile, and adult fish to human pharmaceuticals (D2.3)

 

Available

 

Work Package 3

 

Predicted risk quotients for selected environmentally realistic mixtures of antibiotics and/or anti-cancer drugs using CA/IA/TSP/BINWOE based approaches or advanced modeling. Identification of the main (eco)toxicological drivers in each scenario (D3.1)

 

Available

 

Empirical risk quotients for environmentally realistic mixtures of antibiotics and/or anti-cancer drugs in relevant test systems with human cell lines, selected species of bacteria, algae and fish (embryos) and microbial communities (D3.2)

 

Available

 

Improved mixture modeling approaches and validated tools for estimating the risk of pharmaceutical mixtures, implemented in a software package (D3.3)

 

Available

   

 

Assessment of resistance and tolerance development in STP-derived and natural microbial communities (D3.5)

 

Available

 

Work Package 4

 

Realistic worst-case human exposure scenarios for a selected number of pharmaceuticals (D4.1)

 

Available

 

Probabilistic human exposure assessment for a selected number of pharmaceuticals (D4.2)

 

Available

 

Probabilistic human effect assessment for a selected number of pharmaceuticals (D4.3)

 

Available

 

Probabilistic assessment of the effects of pharmaceuticals on aquatic ecosystems, SWTPs and wildlife (D4.4)

 

Available

 

Work Package 5

Priority list of stable transformation products in terms of toxicity and fate (D5.1)

 

Available

Overview of the detoxification potential of photolysis/UV-disinfection, ozonation, advanced oxidation, chlorination for the cytotoxics and antibiotics investigated in this project evaluated (D5.2)

 

Available

Report on occurrence of stable transformation products of selected cytotoxics and antibiotics in STP effluents and drinking water. Guidelines for benign design of future pharmaceuticals (D5.3)

 

Available

Guidelines for benign design of future pharmaceuticals (and other chemicals) including the evaluation of critical chemical substructures from the aspect of persistency (D5.4)           Available

 

 

Work Package 6

 

Results of the Stakeholder Consultation on Requirements for a Possible Environmental Risk and Hazard Classification System for Pharmaceuticals (D6.1)  +  Annexes

 

Available

 

Assessment of the socio-economic impact and contribution of a classification system on managing risks for human health and ecosystems due to exposure to pharmaceuticals (D6.2)

 

Available

 

Web-based prototype of a classification system with a database including data on case study examples of antibiotics and cytostatics (D6.3)

 

Available

 

Work Package 7

 

Project webpage (D7.5)

 

Available

 

Leaflets for public (D7.1b): english, german, french version

 

Available

 

Interactive web animation (D7.3)

 

Available

 

CD-Rom (D7.4)

 

Available upon request

Policy brief  Available

 

 

Work Package 8

 

Kick off meeting report (D8.1)

 

Available

 

Minutes of Scientific Council meetings (D8.2)

 

Available

 

Minutes of Advisory Group meetings (D8.3)

 

Available

 

Periodic reports at periods specified in the Grant Agreement (D8.4)

 

Available

 

Final reports at the conclusion of the project (D8.5)

 

Available